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. 2018 Sep 7;9:1211. doi: 10.3389/fphys.2018.01211

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Copyright © 2018 Colman, Saxena, Kettlewell and Workman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Parameterizing I_Na through resting membrane potential (RMP) vs dV/dt_max. (A) AP upstroke associated with multiple RMP conditions in experiment (i) and simulation (ii). (B) Relationship between dV/dt_max and RMP in experiment (open circles, blue; n = 10 cells, 4 patients), parameterized I_Na model (solid-purple line, triangles), and original I_Na model (Luo and Rudy, 1991) (dotted orange line, squares). Experimental data: unpublished, Priyanka Saxena.