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AD-lico™ inhibiting IL-6 downstream signaling markers in IL-6 treated THP-1 cells. JAK2 and ERK activation and STAT-3 phosphorylation increases due to activation of the THP-1 cells by IL-6 were dose-dependently blocked by AD-lico™ pretreatment of the cells for 2 h. Genistein, a known kinase inhibitor, served as a positive control in the experiments. This is a representative of three experiments (A). Proposed pathway components of IL-6 signaling in THP-1 cells (B).
