Table 3. Univariate and multivariate analysis for overall survival in test set (n = 382).
| Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|
| n | MST (Mo) | P-value | Hazard Ratio | 95% CI | P-value | ||
| AFP† (U/mL) | ≥ 20 | 165 | 53.3 | 0.1029 | |||
| < 20 | 217 | 57.6 | |||||
| DCP (U/mL) | ≥ 40 | 241 | 49.0 | < .0001 | 2.16 | 1.316–3.661 | 0.0020 |
| < 40 | 141 | 60.8 | |||||
| Triple positive† | Positive | 74 | 34.0 | 0.0082 | 1.09 | 0.677–1.783 | 0.7378 |
| Negative | 308 | 60.2 | |||||
| Tumor size* (mm) | ≥ 34 | 190 | 46.7 | 0.0001 | 1.49 | 0.985–0.9999 | 0.0592 |
| < 34 | 188 | 45.3 | |||||
| Tumor number | Multiple | 106 | 49.1 | 0.0064 | 1.63 | 1.082–2.411 | 0.0195 |
| Solitary | 273 | 57.9 | |||||
| Vascular invasion | Positive | 143 | 46.7 | 0.0005 | 1.39 | 0.933–2.073 | 0.1053 |
| Negative | 233 | 60.7 | |||||
| Gross morphology | SN | 254 | 57.7 | 0.0109 | 0.80 | 0.534–1.213 | 0.2903 |
| Others | 111 | 42.7 | |||||
| Architectural subtype | Macro-T/C | 81 | 38.1 | 0.0002 | 1.56 | 1.006–2.389 | 0.0472 |
| Micro-T/PG | 299 | 58.0 | |||||
Micro-T, microtrabecular; PG, Pseudoglandular; Macro-T, macrotrabecular; SN, simple nodular, des-c-carboxy prothrombin; DCP
† Abnormal level of three HCC markers; alpha-fetoprotein (AFP), lens culinaris agglutinin-reactive fraction of AFP (AFP-L3), and DCP (Kiriyama S et al. Ann Surg 2011)
*Cut-off value was determined by median value.