Table 3.
Screen Failure Categories (N = 7,298)
| AA | Non-AA | P-value | |||
|---|---|---|---|---|---|
| N | % | N | % | ||
| Medical | 1,292 | 73.6% | 4,581 | 82.7% | <0.001 |
|
| |||||
| Abnormal PTT, PLT < 100K, INR > 1.3 | 34 | 1.9% | 122 | 2.2% | 0.503 |
|
| |||||
| Age < 18 or > 80 years | 98 | 5.6% | 884 | 16.0% | <0.001 |
|
| |||||
| Aneurysm, mycotic aneurysm, moyamoya, etc. | 161 | 9.2% | 743 | 13.4% | <0.001 |
|
| |||||
| Craniectomy/other surgical procedures | 21 | 1.2% | 51 | 0.9% | 0.308 |
|
| |||||
| Etiology - tumor | 3 | 0.2% | 47 | 0.8% | 0.003 |
|
| |||||
| GCS < 3/herniation/brain dead/deceased | 25 | 1.4% | 43 | 0.8% | 0.014 |
|
| |||||
| Historic (pre-bleed) Rankin not 0 or 1 | 47 | 2.7% | 96 | 1.7% | 0.013 |
|
| |||||
| ICH > 30 cc on diagnostic CTC | 256 | 14.6% | 700 | 12.6% | 0.035 |
|
| |||||
| Infratentorial bleed | 150 | 8.5% | 451 | 8.1% | 0.591 |
|
| |||||
| No EVD placed | 220 | 12.5% | 733 | 13.2% | 0.449 |
|
| |||||
| No obstruction of 3rd and/or 4th | 261 | 14.9% | 636 | 11.5% | <0.001 |
|
| |||||
| Unstable bleeding | 16 | 0.9% | 75 | 1.4% | 0.146 |
|
| |||||
| Non-medical | 199 | 11.3% | 471 | 8.5% | <0.001 |
|
| |||||
| Improper screening | 9 | 0.5% | 21 | 0.4% | 0.446 |
|
| |||||
| Participation in another trial | 6 | 0.3% | 10 | 0.2% | 0.208 |
|
| |||||
| Patient eligible but refused consent | 54 | 3.1% | 66 | 1.2% | <0.001 |
|
| |||||
| Patient is DNR | 59 | 3.4% | 250 | 4.5% | 0.037 |
|
| |||||
| Study staff not notified within window | 11 | 0.6% | 21 | 0.4% | 0.171 |
|
| |||||
| Study staff unavailable | 2 | 0.1% | 8 | 0.1% | 0.764 |
|
| |||||
| Unable to dose within time window | 58 | 3.3% | 95 | 1.7% | <0.001 |
|
| |||||
| Combination medical and non-medical reasons | 265 | 15.1% | 490 | 8.8% | <0.001 |
|
| |||||
| MD/Surgeon chose not to enroll | 56 | 3.2% | 65 | 1.2% | <0.001 |
|
| |||||
| Not an IVH patient | 18 | 1.0% | 49 | 0.9% | 0.59 |
|
| |||||
| Other | 191 | 10.9% | 376 | 6.8% | <0.001 |
|
| |||||
| Total | 1,756 | 100.0% | 5,542 | 100.0% | |