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. 2018 Sep 4;14(9):e1007257. doi: 10.1371/journal.ppat.1007257

Fig 1. Inducible infectious HIV-1 reservoir viruses can downregulate HLA-C.

Fig 1

(A) Viral isolates were generated from ART-suppressed individuals and infected co-cultured Molt-4 cells, where HLA-C downregulation was determined by comparing HLA-C staining between uninfected and infected cells, discriminated by intracellular staining for Gag. (B) Representative staining of Molt-4 cells in cultures infected with viral isolates that preserve or downregulate HLA-C. HLA-C staining is shown for infected (red) and uninfected cells (black) compared to an isotype control stain (grey). (C) HLA-C downregulation observed for 128 isolates from 19 individuals. Statistical analyses are unpaired t tests.