Figure EV4. A unique epigenetic signature in hypomethylated regions and LINE1 promoters.

1. Enrichment of histone marks associated with promoters against input or histone H3 in two representative HMR_−L1s. Y‐axis represents reads per million uniquely mapped reads (RPM). The numbers in parentheses represent the coverage for a whole genome. Only the results of one of the two replicates are shown when there are biological replicates (Appendix Table S1), as the results of the two replicates were similar. The ChIP‐seq data with biological replicates are indicated as “rep1” or “rep2” in the panel. HMR_−L1 shown in the left panel is located in an intergenic region on chromosome 1. HMR_−L1 shown in the right panel is located within the Rasgrf1 differentially methylated region (DMR).
2. L1 promoters are active in 15.5 dpc prospermatogonia. ChIP‐seq signals normalized by H3 or input signals are shown. For the analyses of L1Md_Tf and L1Md_A, all the reads were mapped to their consensus sequences. For transcription start sites (TSSs), unique reads were used for mapping, and the average signals across all coding genes are shown.