Table 2.
Patterns of angiotensin‐converting enzyme inhibitor use stratified by indication
| Indication (patients) | Pattern (n) % | |
|---|---|---|
| Heart failure ( n = 3762) | Persistent (2507) 66.6% | |
| Nonpersistent (1255) 33.4% | Stop (561) 44.7% | |
| Switch to ARB (506) 40.3% | ||
| Restart (188) 15.0% | ||
| Hypertension ( n = 146 275) | Persistent (88 632) 60.6% | |
| Nonpersistent (57 643) 39.4% | Stop a (24 206) 42.0% | |
| Switch to ARB (23 271) 40.4% | ||
| Restart (10 166) 17.6% | ||
| Myocardial infarction ( n = 10 639) | Persistent (7826) 73.6% | |
| Nonpersistent (2813) 26.4% | Stop (1200) 42.7% | |
| Switch to ARB (1187) 42.2% | ||
| Restart (426) 15.1% | ||
| Renal disease ( n = 9299) | Persistent (4727) 50.8% | |
| Nonpersistent (4572) 49.2% | Stop (2493) 54.5% | |
| Switch to ARB (1262) 27.6% | ||
| Restart (817) 17.9% | ||
| More than one indication ( n = 43 753) | Persistent (25 555) 58.4% | |
| Nonpersistent (18 198) 41.6% | Stop b (8399) 46.2% | |
| Switch to ARB (6650) 36.5% | ||
| Restart (3149) 17.3% | ||
| None of the mentioned indications ( n = 40 274) | Persistent (23 965) 59.5% | |
| Nonpersistent (16 309) 40.5% | Stop (8817) 54.1% | |
| Switch to ARB (4545) 27.9% | ||
| Restart (2947) 18.1% | ||
| Total ( n = 254 002) | Persistent (153 212) 60.3% | |
| Nonpersistent (100 790) 39.7% | Stop (45 676) 45.3% | |
| Switch to ARB (37 421) 37.1% | ||
| Restart (17 693) 17.6% | ||
a
Switched to calcium channel blockers (17.2%), diuretics (6.3%), combination of antihypertensives (5.0%), β‐blockers (3.6%) and other antihypertensives (0.1%).
b
Two subgroups: a) more than one indication including hypertension (90.5%) and b) not including hypertension (9.5%). Group A percent switched to calcium channel blockers (10.0%), diuretics (6.3%), combination of antihypertensives (3.3%), β‐blockers (3.2%) and other antihypertensives (0.3%).
ARB, angiotensin II‐receptor blocker