Table 5.
Results for the nangibotide population final model
| Parameter (unit) | Model estimate (SE%) | IIV CV% (SE%) |
|---|---|---|
| V 1 (l) | 16.7 (7.5) | 13.9 (87) |
| CL (l h −1 ) a | 463 (4.0) | 7.83 (47) |
| BW on CL b | 0.725 (35.2) | ‐ |
| V 2 (l) | 15.9 (15.0) | ‐ |
| Q (l h −1 ) | 9.4 (17.3) | ‐ |
| Alpha (h −1 ) | 28.3 | |
| Beta (h −1 ) | 0.579 | |
| t 1/2α (min) | 1.47 | |
| t 1/2β (min) | 71.8 | |
| Effective t 1/2 (min) | 2.91 | |
| Residual error (CV%) | 33.2 (5.45) |
CV, coefficient of variation; IIV, inter‐individual variability; SE, standard error
a
for 70 kg
b
CLi = CL × (BWi/70) 0.725