Figure 2.

Mean (SD) serum concentration–time profiles of cytochrome P450 (CYP) probe substrates (midazolam, warfarin, dextromethorphan, caffeine) and mean (SD) CYP probe substrate metabolite to parent (5‐hydroxyomeprazole/omeprazole) serum concentration ratio–time profile following oral single‐dose administration of CYP probe substrates (A) midazolam 2 mg [CYP3A4 probe]; (B) S‐warfarin 10 mg + vitamin K 10 mg [CYP2C9 probe]; (C) omeprazole 40 mg [CYP2C19 probe]; (D) dextromethorphan 30 mg [CYP2D6 probe]; (E) caffeine 200 mg [CYP1A2 probe]) with or without coadministration of multiple doses of tildrakizumab SC (200 mg on Days 1 and 29) in subjects with moderate to severe psoriasis