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. Author manuscript; available in PMC: 2019 Sep 14.
Published in final edited form as: ACS Infect Dis. 2018 Jul 23;4(9):1385–1394. doi: 10.1021/acsinfecdis.8b00115

Figure 1.

Figure 1

CSP-mediated QS circuit of S. mutans. The CSP pro-peptide, ComC, is processed and secreted by the dedicated ABC transporter (ComAB) as 21-CSP, which is further cleaved by a membrane protease, SepM, to form the active 18-CSP signal. 18-CSP interacts with the cognate transmembrane histidine-kinase receptor ComD, leading to phosphorylation of ComE, a response regulator, and results in autoinduction of the QS circuitry, the production of bacteriocins, and expression of comX, which codes for additional QS-regulated phenotypes.