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. Author manuscript; available in PMC: 2019 Sep 14.
Published in final edited form as: ACS Infect Dis. 2018 Jul 23;4(9):1385–1394. doi: 10.1021/acsinfecdis.8b00115

Figure 2.

Figure 2

Plot of the ratio of 18-CSP alanine analogs EC50 values divided by the EC50 value of 18-CSP in the SAB249 strain. The plot reveals a periodic sharp reduction in activity every 3–4 residues along the peptide sequence, consistent with an α-helix conformation. Striped bars represent analogs with EC50 values >1,000 nM, thus the EC50 ratio is >160. >8-fold decrease in potency was considered significant (dashed line).