Skip to main content
. Author manuscript; available in PMC: 2019 Sep 28.
Published in final edited form as: J Control Release. 2018 Aug 11;286:415–424. doi: 10.1016/j.jconrel.2018.08.018

Fig. 3. Fibrinogen directly increased the global transduction efficiency of AAV9 vectors.

Fig. 3.

1×1010 vg of AAV9/luc were incubated with fibrinogen at the normal physiological concentration (Fib-PBS group) or PBS (PBS group) at 4 °C for 2 hours and then injected into C57BL/6 mice via the retro-orbital vein. The other group (PBS-Fib) was injected with non-incubated AAV9 and fibrinogen. Imaging was taken at day 7, and the photon signal was measured and calculated. (A) Fibrinogen enhanced AAV9 transduction. (B) The effect of AA9 transduction with fibrinogen at different concentrations. The data represents the average and standard deviation from 5 mice. The asterisk indicates the significant difference (p < 0.05).