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. Author manuscript; available in PMC: 2019 Sep 28.
Published in final edited form as: J Control Release. 2018 Aug 11;286:415–424. doi: 10.1016/j.jconrel.2018.08.018

Fig. 5. The combination of serum proteins did not further enhance the global transduction of AAV9 vectors.

Fig. 5.

1×1010 vg of AAV9/luc were incubated with either fibrinogen, FN, vWF, or the combination of these three proteins at a 10-fold dilution of the normal physiological concentration for 2 hours at 4 °C and then injected into C57BL/6 mice via the retro-orbital vein. Imaging was taken at day 7 (A). The photon signal was measured and calculated for luciferase expression (B and C). The AAV9 genomic copy number was measured by qPCR assay (D). The data represents the average and standard deviation from 5 mice. The asterisk indicates the significant difference (p<0.05).