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. Author manuscript; available in PMC: 2019 Sep 28.
Published in final edited form as: J Control Release. 2018 Aug 11;286:415–424. doi: 10.1016/j.jconrel.2018.08.018

Fig. 8. Both fibrinogen and cryoprecipitate slowed down the clearance of AAV9 vectors in bloodstream.

Fig. 8.

1×1011 vg of AAV9/luc were incubated with either fibrinogen or cryoprecipitate at 4 °C for 2 hours and then injected into C57BL/6 mice via the retro-orbital vein. The blood was collected from the mice with cryoprecipitate at 5 minutes, 2-, 24-, 48-, and 72- hours after AAV9 injection, or at 20 minutes, 2-, 24-, 48-, and 72- hours in the mice treated with fibrinogen and AAV9. The AAV9 gene copy number in plasma was detected by qPCR. The data represents the average and standard deviation from 5 mice. The asterisk indicates significant difference (p < 0.05), and the “ns” indicates no significant difference (p > 0.05).