Table 1.

Characteristics and Outcomes of Sepsis Patients that Passed versus Failed SEP-1

Clinical Characteristics	Pass (n=281)	Fail (n=570)	p-value
Median Age (IQR)	68 (57-81)	67 (57-80)	0.319
Male Sex	155 (55.2%)	303 (53.2%)	0.582
White Race	223 (79.4%)	446 (78.3%)	0.710
Median Elixhauser Score (IQR)	11 (5-16)	11 (5-17)	0.608
Academic vs Community Hospital	144 (51.3%)	301 (52.8%)	0.668
Discharged in Study Year 2 (vs Year 1)	158 (56.2%)	278 (48.8%)	0.041*
Discharging Service
Medical	206 (73.3%)	407 (71.4%)	0.560
Surgical	4 (1.4%)	37 (6.5%)	0.001*
Other	71 (25.3%)	125 (21.9%)	0.277
Sepsis Onset in Emergency Department	232 (82.6%)	421 (73.9%)	0.005*
Hospital-Onset Sepsis (>48 hours from presentation)	12 (4.3%)	63 (11.1%)	0.001*
Initial Sepsis Organ Dysfunction
Hypotension	87 (31.0%)	189 (33.2%)	0.520
Lactate >2 and <4	80 (28.5%)	138 (24.2%)	0.181
Lactate ≥4	18 (6.4%)	72 (12.6%)	0.006*
Respiratory Failure	13 (4.6%)	37 (6.5%)	0.277
Creatinine >2	20 (7.1%)	36 (6.3%)	0.658
Bilirubin >2	8 (2.9%)	13 (2.3%)	0.617
Platelets <100	10 (3.6%)	15 (2.6%)	0.452
INR >1.5 or PTT >60	4 (1.4%)	9 (1.6%)	0.862
MD documentation of severe sepsis/septic shock	41 (14.6%)	61 (10.7%)	0.101
Septic Shock (Persistent Hypotension or Lactate ≥4)	25 (8.9%)	112 (19.7%)	<0.001*
Positive blood cultures	75 (26.7%)	160 (28.1%)	0.672
Explicit Infectious Symptoms at Presentation	197 (70.1%)	310 (54.4%)	<0.001*
Body Site Source of Infection
Pneumonia	113 (40.2%)	188 (33.0%)	0.038*
Urinary Tract Infection	66 (23.5%)	137 (24.0%)	0.860
Intra-abdominal Infection	50 (17.8%)	105 (18.4%)	0.824
Other	52 (18.5%)	140 (24.6%)	0.047*
Outcomes
Required ICU Stay	142 (50.5%)	299 (52.5%)	0.598
Median ICU Length of Stay (IQR)	3 (2-6)	4 (2-9)	0.030*
Median Hospital LOS	7 (5-12)	8 (5-13)	0.132
In-Hospital Death	31 (11.0%)	105 (18.4%)	0.006*

^*Indicates statistically significant variables at p<0.05.