. Author manuscript; available in PMC: 2019 Oct 1.

Published in final edited form as: Alzheimer Dis Assoc Disord. 2018 Oct-Dec;32(4):270–275. doi: 10.1097/WAD.0000000000000253

Table 2.

Adjusted hazard ratios (aHR) for dementia by midlife pulmonary function modelled continuously and in quintiles

	FEV₁ (n=26858; 7359 cases)		FEV₂ (n=16289; 3787 cases)		VC (n=27384; 7518 cases)
	Model 1 HR (95% CI)	Model 2 HR (95% CI)	Model 1 HR (95% CI)	Model 2 HR (95% CI)	Model 1 HR (95% CI)	Model 2 HR (95% CI)
Continuous^*	1.15 (1.11, 1.20)	1.13 (1.09, 1.18)	1.17 (1.11, 1.23)	1.13 (1.08, 1.19)	1.16 (1.12, 1.21)	1.14 (1.10, 1.18)

Quintile
1- Worst	1.29 (1.19, 1.39)	1.24 (1.14, 1.34)	1.37 (1.22, 1.54)	1.27 (1.13, 1.43)	1.34 (1.23, 1.45)	1.28 (1.17, 1.39)
2	1.19 (1.10, 1.29)	1.16 (1.08, 1.26)	1.29 (1.15, 1.44)	1.24 (1.10, 1.39)	1.23 (1.13, 1.34)	1.20 (1.11, 1.30)
3	1.18 (1.09, 1.28)	1.16 (1.07, 1.26)	1.15 (1.03, 1.29)	1.11 (1.00, 1.25)	1.15 (1.07, 1.24)	1.13 (1.05, 1.22)
4	1.04 (0.97, 1.13)	1.04 (0.96, 1.12)	1.15 (1.03, 1.28)	1.12 (1.01, 1.25)	1.08 (1.00, 1.16)	1.07 (0.99, 1.16)
5- Best	ref	ref	ref	ref	ref	ref

Notes:

Continuous midlife pulmonary function was reverse coded such that high values reflect worse pulmonary function. Midlife pulmonary function quintiles estimated separately for men and women. Model 1 adjusts for demographics (age, race/ethnicity, education) and height. Model 2 adjusts demographic, height, midlife health indicator (hypertension, body mass index, smoking status), and late-life health indicator (stroke, diabetes, heart failure).