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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Cancer Metastasis Rev. 2018 Dec;37(4):733–748. doi: 10.1007/s10555-018-9728-y

Figure 1.

Figure 1

The TRAIL apoptosis pathway. In response to TRAIL stimulation, FADD, caspase-8/10 and c-FLIP are recruited to death receptors DR4 and DR5 to form the death-inducing signaling complex (DISC), which triggers apoptosis. DcR1, DcR2 and osteoprotegerin are three decoy receptors. DcR1 lacks intracellular domain while DcR2 contains truncated death domain. Osteoprotegerin is a soluble decoy receptor.