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. Author manuscript; available in PMC: 2019 Sep 28.
Published in final edited form as: J Control Release. 2018 Aug 4;286:279–288. doi: 10.1016/j.jconrel.2018.08.007

Figure 4.

Figure 4.

Arthritis treatment with liposomal IL-27. Lewis rats were immunized s.c. at the base of the tail with Mtb (1.5 mg/rat). Beginning at the onset of arthritis, groups of rats (n= 5–7 per group) were treated i.v. on day 10 and 12 (arrows) after Mtb immunization with free IL-27, ART-1-IL-27 liposomes, control-IL-27 liposomes, or ART-1 liposomes lacking IL-27. A group of arthritic rats given PBS served as an untreated control group. (A) Arthritic scores (mean ± SEM) of rats are shown. P ˂0.05 was considered statistically significant. The differences in arthritic scores of each of the following 4 pairs of groups was significant: ART-1-IL-27 liposomes versus control rats; ART-1-IL-27 liposomes versus ART-1 liposomes lacking IL-27; ART-1-IL-27 liposomes versus control-IL-27 liposomes, and ART-1-IL-27 liposomes versus free IL-27. (B) Representative photographs of hind paws and (C) images of H&E-stained hind paw sections of the indicated groups of rats are shown. In ‘C’, histopathological features associated with arthritis are shown: B, bone; C, cartilage; JS, joint space; P, pannus.