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. Author manuscript; available in PMC: 2019 Sep 28.
Published in final edited form as: J Control Release. 2018 Aug 4;286:279–288. doi: 10.1016/j.jconrel.2018.08.007

Figure 5:

Figure 5:

Serum chemistry analysis to assess the systemic exposure profiles of various treatment modalities. Blood samples were collected from rats (n= 4–5 per group) subjected to different treatment regimen (shown in Fig 4) on d 25 after Mtb immunization and serum was separated for testing. Serum levels of (A) aspartate aminotransferase (AST), alanine transaminase (ALT), and total bilirubin (TBIL) indicative of hepatobiliary effects; (B) lactate dehydrogenase (LDH) indicative of acute/chronic tissue damage; and (C) blood urea nitrogen (BUN), creatinine (CREAT), and BUN/Creatinine (B/C) ratio indicative of renal effects were measured. (*, p<0.05)