Skip to main content
. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Biotechnol Prog. 2018 Mar 31;34(4):1045–1058. doi: 10.1002/btpr.2629

Figure 5. Biological drug testing data.

Figure 5

Differences in diameters and GAG contents of macrospheroids made of 100,000 OACs, which were cultured for 3 weeks in the presence of either TNF-α, IL-1β or working solutions of MCMh.s. (a) or MCMF (b) alone, and combined with tested biological drugs. Diameter measurement results in (a) n=8 and (b) n=6, as well as GAG concentrations (n=3) were compared by one-way ANOVA; p < 0.05 (*), p < 0.01 (**) and p < 0.001 (***). Legend: ø- chondrogenic medium (control 1); MCM ø - ½ chondrogenic medium + ½ THP-1 medium (control 2); MCMh.s. or MCMF - MCM supplemented with human serum or FBS; TNF -TNF-α (1 ng/mL, if not specified otherwise); IL - IL1β (1 ng/mL) ; ADA = adalimumab (1 µg/mL); IFX = infliximab (1 µg/mL); ETA = etanercept (1 µg/mL); ANA = anakinra (1 µg/mL).