Table 1.

Roles of chemokine receptors in biological functions involved in AD.

Effects on	Receptor	Biological and molecular consequences	Refs
Aβ levels	CX3CR1	Inhibition of microglial phagocytosis of Aβ peptides	[24], [25]
	CXCR2	Production of Aβ peptides	[30], [31]
	CXCR3	Inhibition of microglial phagocytosis of Aβ peptides	[33]
	CCR2	Clearance of Aβ peptides	[37], [40], [43], [44]
	CCR3	Production of Aβ peptides	[47]
Tau phosphorylation	CX3CR1	Inhibition of hyperphosphorylation of Tau	[15], [22], [23], [26]
	CCR3	Hyperphosphorylation of Tau	[47]
Synaptic function	CX3CR1	Regulation of cognitive function, loss of neurons	[19], [20], [21], [27]
	CXCR2	Impairment of long-term potentiation	[29]
	CXCR3	Impairment of long-term potentiation	[34]
	CCR3	Loss of dendritic spines	[47]
	CCR5	Impairment of memory and synaptic plasticity	[48], [52], [53]
Neuroinflammatory	CX3CR1	Control of microglial activation and IL-1β release	[22]
response	CCR3	Microglial activation	[47]
Cellular chemotaxis	CXCR2	Recruitment of T-lymphocytes in the brain	[32]
	CCR2	Recruitment of perivascular macrophages	[40]
	CCR5	Recruitment of T-lymphocytes in the brain	[49], [50]