Table 2.
GSEA of Biological pathways in groups defined by trajectories of anxiety disorders.
| Significant enrichment scores based on GSEA | ||||
|---|---|---|---|---|
| TDC | Persistent | Incident | Remittent | |
| Nervous System processes | ||||
| Neurogenesis | −0.3781 | NS | −0.3549 | −0.5699 |
| Neuron Differentiation | −0.3894 | NS | −0.3735 | −0.6113 |
| Generation of Neurons | −0.3638 | NS | −0.3689 | −0.5911 |
| Nervous System Development | −0.3807 | 0.3156 | −0.3859 | −0.4942 |
| Central Nervous System Development | −0.5184 | 0.4273 | NS | NS |
| Neuron development | NS | NS | 0.3988 | −0.5688 |
| Neurite development | NS | NS | −0.3712 | NS |
| Signalization processes | ||||
| Signal transduction | −0.3332 | −0.3146 | NS | −0.355 |
| Cell surface receptor linked signal transduction GO:0007166 | −0.3373 | NS | NS | NS |
| Intracellular signaling cascade | −0.3335 | NS | NS | NS |
| Regulation processes | ||||
| Regulation of molecular function | NS | −0.4451 | NS | NS |
| Regulation of catalytic activity | NS | −0.466 | NS | NS |
| Negative regulation of catalytic activity | NS | −0.4222 | NS | NS |
| Regulation of signal transduction | −0.3928 | NS | NS | NS |
| Negative regulation of cellular process | −0.2951 | NS | NS | −0.34 |
| Regulation of developmental process | 0.2634 | −0.373 | −0.4652 | NS |
| Regulation of cellular metabolic process | −0.3065 | −0.345 | NS | NS |
| Regulation of gene expression | −0.2935 | −0.3588 | NS | NS |
| Regulation of transcription DNA dependent | −0.2624 | −0.36 | NS | NS |
| Positive regulation of biological process | −0.2886 | NS | NS | NS |
| Regulation of metabolic process | −0.3041 | NS | NS | NS |
| Regulation of nucleobase nucleoside nucleotide and nucleic acid metabolic process | −0.2911 | −0.3436 | NS | NS |
| Regulation of metabolic process | −0.3041 | −0.3465 | NS | NS |
| Regulation of RNA metabolic process | −0.2658 | −0.3497 | NS | |
| Negative regulation of developmental process | 0.305 | NS | NS | NS |
| Positive regulation of cellular process | −0.2929 | NS | NS | NS |
| Negative regulation of biological process | −0.2887 | NS | NS | −0.3493 |
| Regulation of transcription | −0.2844 | −0.3604 | NS | NS |
| Regulation of cell proliferation | −0.402 | NS | NS | NS |
| Positive regulation of multicellular organismal process | 0.3788 | NS | NS | NS |
| Regulation of multicellular organismal process | −0.2907 | NS | NS | NS |
| Development processes | ||||
| System development | NS | −0.2963 | −0.387 | −0.3826 |
| Muscle development | −0.317 | NS | NS | NS |
| Cell development | −0.2801 | −0.3328 | −0.4431 | NS |
| Tissue development | −0.4514 | NS | NS | NS |
| Multicellular organismal development | −0.4169 | −0.287 | −0.3736 | NS |
| Anatomical structure development | −0.315 | −0.2841 | −0.3904 | −0.3719 |
| Organ development | −0.3261 | NS | −0.3861 | NS |
| Ectoderm development | −0.5677 | NS | NS | NS |
| Processes involved with protein and protein synthesis | ||||
| Transcription | −0.2622 | −0.381 | NS | NS |
| Transcription DNA dependent | −0.2476 | −0.3896 | NS | NS |
| Post translational protein modification | −0.3913 | −0.3351 | NS | NS |
| Cellular protein metabolic process | −0.3728 | NS | NS | NS |
| Protein kinase cascade | −0.2912 | NS | NS | NS |
| Protein metabolic process | −0.3696 | NS | NS | NS |
| Protein modification process | −0.3636 | −0.3603 | NS | NS |
| Protein aminoacid phosphorylation | −0.3672 | NS | NS | NS |
| RNA biosynthetic process | −0.2474 | −0.3907 | NS | NS |
| Other processes | NS | NS | ||
| Biopolymer metabolic process | −0.318 | −0.3353 | NS | NS |
| Biopolymer modification | −0.3622 | −0.2878 | NS | NS |
| Anatomical structure morphogenesis | −0.282 | −0.2791 | −0.3262 | −0.3735 |
| Defense response | 0.3405 | NS | NS | NS |
| Cell proliferation GO:0008283 | −0.275 | NS | NS | NS |
| Cellular macromolecule metabolic process | −0.3712 | NS | NS | NS |
| Phosphorylation | −0.3768 | NS | NS | NS |
| Leukocyte activation | 0.3234 | NS | NS | NS |
| Locomotory behavior | NS | 0.1618 | NS | NS |
Note: GSEA, Gene set enrichment analysis; TDC, Typically Developing Controls; NS, No significant (p > 0.001). All biological pathways significant at false discovery rate (FDR) correction. Signal negative represents DNA hypomethylated biological pathways.