Fig. 2.

Discordance between ERV-estimated and common SNV-estimated mutation rates. a Relationship between 7-mer relative mutation rates estimated among BRIDGES ERVs (x-axis) and the 1000G intergenic SNVs (y-axis) on a log-log scale. We note that the strength of this correlation is driven by hypermutable CpG > TpG transitions. b Type-specific 2D-density plots, as situated in the scatterplot of a. The dashed line indicates the expected relationship if no bias is present. c Heatmap showing ratio between the relative mutation rates for each 7-mer mutation subtype. Subtypes with higher rates among the 1000G SNVs (relative to ERV-derived rates) are shaded gold, and subtypes with lower rates in the 1000G SNVs are shaded green. Relative differences are truncated at 2 and 0.5, as only 2.5% of subtypes showed differences beyond this range