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. 2018 Sep 14;9:3744. doi: 10.1038/s41467-018-06275-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Fn14 is degraded in lysosomes and undergoes trafficking through Golgi. a HeLa cells were treated with BafA and TWK as indicated, extracted proteins were immunoblotted (upper panel) and lysosomal flux was calculated (lower panel) (*P < 0.05, n = 7 biological repeats). b–d Cells were treated as in a, immunostained for Fn14 and LAMP1 (b), GRASP65 (c), or ERGIC-53 (d), and analyzed by confocal microscopy (scale bar, 20 µm). Large magnification of stained cells is presented in the right column. Comparisons by T test; mean ± s.e.m.