Fig. 7.

Regulation of Fn14 by the autophagic machinery. GABARAP-mediated autophagy is responsible for the main pool of the cellular Fn14 and in its absence the receptor accumulates in ERGIC. GATE-16-mediated autophagy and the canonical MVB pathway are responsible in parallel for degradation of Fn14 in endocytic compartments. In absence of GATE-16, Fn14-positive endosomes accumulate at the vicinity of open phagophores. Recruitment of Fn14 to either GABARAP- or GATE-16-dependent autophagosomes is mediated by the cargo receptor p62. Recruitment of internalized Fn14 through the GATE-16-dependent pathway requires TRAF2. The mechanism responsible for recruitment Fn14 to GABARAP-dependent autophagy is still unknown