Fig. 3.

Reconstruction of FA metabolic pathways from multi-omics data and FA-glycerophospholipid species correlations. a Cellular de novo synthesis of palmitate, elongation to saturated and desaturation to monounsaturated FA. b Metabolism of n-3 and n-6 PUFA. (I–III) indicate the key processes altered in GF compared to SPF mice. c Transcription factors and regulators controlling a and b. d Correlation of product to precursor ratios with the appropriate gene or protein expression for reactions (II) and (III). e Correlation of FA species ratios with corresponding PC or LPC ratios for reactions (II) and (III). f Legend for the figure highlighting the strength and direction of the association for all molecular entities shown. FA: fatty acid, LPC: Lyso-PC, MUFA: monounsaturated fatty acids, PC: phosphatidylcholine, PUFA: polyunsaturated fatty acids, SAFA: saturated fatty acids, for other abbreviations, see Table 1