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. 2018 Sep 14;9:3771. doi: 10.1038/s41467-018-06112-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Catabolic capabilities across host-restricted serovars. a Decision tree depicting differential nutrient utilization capabilities in 410 GEMs classified as host restricted (specialists) or non-host restricted (generalists). Specialists are distinguished from generalists by a general trend toward losing catabolic capabilities. b Catabolic capabilities of 67 host-restricted strains on 18 nutrient conditions (see Supplementary Fig. 6 for heat map). The conservation of certain catabolic capabilities among serovars restricted to a common niche hints at the availability of certain nutrients in a niche and highlights the importance of that function for survival. The classification of each serovar by its known colonization niche is listed along with the number of strains per serovar included in the analysis, see Supplementary Data 1 for more details on the strains. The nutrient sources are classified as C for carbon, P for phosphate, and N for nitrogen source and their basis to support growth in aerobic (O2+) and anaerobic (O2−) conditions are shown