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. 2018 Sep 14;9:3748. doi: 10.1038/s41467-018-06145-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Expansion of the inner pore permitted mainly by the GluN1 M4 conserved glycine facilitates NMDAR gating and Ca²⁺ permeation. Cartoon of NMDAR pore structure, including the influence of the GluN1 M4 on open state stability and selectivity filter integrity. Subunits are colored light orange (GluN1) and gray (GluN2)