Table 2.
B- and T-cell epitopes that include residues predicted simultaneously by at least two predictors among BepiPred (B-cell lineal), DiscoTope (B-cell conformational), NetMHCI (T-cell for MHCI) and NetMHCII (T-cell for MHCI) are highlighted in bold. Core amino acids of MHC II peptides are underlined.
| Regions | Linear B-cell epitopes | Conformational B-cell epitopes | T-cell epitopes for MHC II (SB) | T-cell epitopes for MHC I (WB) |
|---|---|---|---|---|
| 1 |
PSSFQEKDADTLPGKVE (82–98) |
FQEKD (85–89) |
HLA-DRβ1*13:02 GKVEQSTLFSVTNPV (95–109) |
HLA-B*35:01 LIVGDPSSF (77–85), HLA-B*35:01 LPGKVEQSTLF (93–103) HLA-A*02:01 KVEQSTLFSV (96–105) HLA-C*07:02 SFQEKDADTL (84–93) |
| 2 |
NNQAGISFEGGKASFG (412–427) |
GIS (416–418) E (420) |
HLA-DRβ1*01:01 AGISFEGGKASFGGG (415–429) |
HLA-B*35:01 VSIQNNQAGISF (408–419) |
| 3 |
FASEDGDLSPESSISSEELA (763–782) |
SEELAL (778–783) |
HLA-DRβ1*01:01 FITAANQALFASEDG (754–768) |
HLA-B*35:01 FASEDGDLSPES (763–774) |
| 4 | LREEDKLDGQ (825–834) |
HLA-DRβ1*13:02 GQIPEVLISGNAGDV (833–848) |
HLA-A*02:01 KLDGQIPEVLI (830–840) |
|
| 5 |
PEIEEDTYGHMGDWSEAKIQ (1171–1190) |
IHVATPEI (1166–1173) |
HLA-DRβ1*01:01 WSEAKIQDGTLVINW (1184–1198) |
HLA-B*35:01 TPEIEEDTY (1170–1178) |
| 6 |
LGESSASWT (1353–1361) |
HLA.DRβ1*01:01 RYGVLGESSASWTSR (1349–1363) |