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. 2018 Jun 2;41(2):102–108. doi: 10.1016/j.bj.2018.02.004

Fig. 2.

Fig. 2

Distinct functions of PEDF in lipid metabolic disorders. On one hand, PEDF exerts its anti-inflammatory and anti-oxidative properties in maintaining the homeostasis of hepatic lipid accumulation. On the other hand, increased PEDF in adipose tissue has the potential to initiate a cascade of events that may eventually lead to insulin resistance.