Table 2.
Distribution of MTHFR 677C > T and 1298A > C genotypes and allelic frequencies in LCPD patients and control subjects.
| Genotypes | Cases (n = 45) | Control (n = 55) | OR (95% CI) | P-value |
|---|---|---|---|---|
| MTHFR 677C > T | ||||
| Genotype | ||||
| CC | 27 (60.0) | 34 (61.8) | Ref. | |
| CT | 15 (33.3) | 19 (34.6) | 0.947 (0.412–2.178) | 0.899 |
| TT | 3 (6.7) | 2 (3.6) | 1.893 (0.302–11.852) | 0.495 |
| Allele | ||||
| C | 69 (76.7) | 87 (79.1) | 0.869 (0.444–1.699) | 0.681 |
| T | 21 (23.3) | 23 (20.9) | 0.946 (0.474–1.888) | 0.874 |
| Dominant (TT + CT vs. CC) | 1.079 (0.482–2.420) | 0.853 | ||
| Recessive (TT vs. CT + CC) | 1.893 (0.302–11.852) | 0.495 | ||
| MTHFR 1298A > C | ||||
| Genotype | ||||
| AA | 23 (51.1) | 30 (54.5) | Ref. | |
| AC | 20 (44.5) | 24 (43.7) | 1.033 (0.467–2.285) | 0.935 |
| CC | 2 (4.4) | 1 (1.8) | 2.512 (0.220–28.634) | 0.458 |
| Allele | ||||
| A | 66 (73.3) | 84 (76.4) | 0.851 (0.448–1.617) | 0.651 |
| C | 24 (26.7) | 26 (23.6) | 1.175 (0.618–2.232) | 0.623 |
| Dominant (TT + CT vs. CC) | 1.148 (0.521–2.528) | 0.732 | ||
| Recessive (TT vs. CT + CC) | 2.512 (0.220–28.634) | 0.458 | ||
OR: Odds Ratio; CI: Confidence Interval.