Table 3.
Distribution of TNF-α −308G > A and −238G > A genotypes and allelic frequencies in LCPD patients and control subjects.
| Genotypes | Cases (n = 45) | Control (n = 55) | OR (95% CI) | P-value |
|---|---|---|---|---|
| TNF-α -308G > A | ||||
| Genotype | ||||
| GG | 26 (57.8) | 30 (54.5) | Ref. | |
| GA | 17 (37.8) | 23 (41.8) | 0.845 (0.377–1.892) | 0.682 |
| AA | 2 (4.4) | 2 (3.6) | 1.233 (0.167–9.115) | 0.838 |
| Allele | ||||
| G | 69 (76.7) | 83 (75.4) | 1.069 (0.556–2.055) | 0.842 |
| A | 21 (23.3) | 27 (24.6) | 0.936 (0.487–1.799) | 0.842 |
| Dominant (AA + GA vs. GG) | 0.877 (0.396–1.941) | 0.746 | ||
| Recessive (AA vs. GA + GG) | 1.233 (0.167–9.115) | 0.838 | ||
| TNF-α -238G > A | ||||
| Genotype | ||||
| GG | 29 (64.4) | 37 (67.2) | Ref. | |
| GA | 15 (33.3) | 18 (32.8) | 1.028 (0.445–2.375) | 0.949 |
| AA | 1 (2.2) | 0 (0.0) | 3.742 (0.149–94.097) | 0.423 |
| Allele | ||||
| G | 73 (81.1) | 92 (83.6) | 0.840 (0.405–1.744) | 0.640 |
| A | 17 (18.9) | 18 (16.4) | 1.190 (0.573–2.471) | 0.640 |
| Dominant (AA + GA vs. GG) | 1.134 (0.494–2.602) | 0.766 | ||
| Recessive (AA vs. GA + GG) | 3.742 (0.149–94.097) | 0.423 | ||
OR: Odds Ratio; CI: Confidence Interval.