Fig. 1.

The Structure of PTEN. PTEN encodes a 403-amino acid peptide, which is composed of a phosphatidylinositol-4, 5-bisphosphate-binding domain (PBD) (residues 1–13), a catalytic phosphatase domain (PD) (residues 14–185), a C2 membrane binding domain (C2D)(residues 186–350), and a C-terminal tail (residues 351–403). The PD includes a conserved catalytic motif HCKAGKGR. The C2 domain includes two tyrosine phosphorylation sites (Y240 and Y315). There are two PDZ-binding domains (PDZ-BD) and six phosphorylation sites in the C-terminal tail. PDZ, post-synaptic density protein (PSD95), Drosophila discs large (Dlg) and the tight junction protein zonula occludens-1 (ZO-1)