Table 1.

Regulation of PTEN expression by miRNAs

MiRNA	PTEN expression	Mechanism	Disease	Reference
miR-21	Down	directly targeting PTEN mRNA	Gastric cancer, HNSCC, CCRCC	[52–54]
miR-130	Down	directly targeting PTEN mRNA	Bladder cancer, Breast invasive carcinoma, HCAECs injury, Inflammatory responses, PD, Lung adenocarcinoma, Colon adenocarcinoma	[55–58]
miR-130	Up	directly targeting PTEN mRNA	NSCLC	[59]
miR-451	Up	directly targeting PTEN mRNA	Lung cancer, Ovarian cancer	[60, 61]
miR-221 /222	Down	directly targeting PTEN mRNA	NSCLC,HCC, TRAIL-induced cell death	[62]
miR-301a	Down	directly targeting PTEN mRNA	Breast cancer, Neuronal death, Ewing’s carcoma, Melanoma, Insulin resistance	[63–67]
miR-214	Down	directly targeting PTEN mRNA	Tumorigenesis, Immunology, Cardiac injury	[68–71]
miR-494	Down	directly targeting PTEN mRNA	Ischemia/Reperfusion -induced myocardial injury	[72, 73]
miR-155-5p/130b/616/19/92a/10a/106a/429/26a /486-5p	Down	directly targeting PTEN mRNA	HCC, NSCLC, Breast cancer, Lung cancer, Colorectal Cancer, Chronic myeloid leukemia, Intestinal cancer, Acute T-cell lymphoblastic leukemia	[74–84]
miR-29	Up	inducing the hypomethylation of PTEN promoter by inhibiting DNMT1, DNMT3b and SET1A expression	Liver fibrosis	[87, 88]
miR-101	Up	inducing the hypomethylation of PTEN promoter by inhibiting DNMT3A expression	Lung cancer	[89, 90]
miR-185	Up	inducing the hypomethylation of PTEN promoter by inhibiting DNMT1 expression	HCC	[91]