Table 2.
Regulation of PTEN expression by lncRNAs
| LncRNA | PTEN expression | Mechanism | MiRNA | Disease | Reference |
|---|---|---|---|---|---|
| PTENP1 | Up | acting as ceRNAs | miR-21, miR-17, miR-214, miR-19, miR-20, miR-93, miR-106b, miR-26 | CCRCC, OSCC, HCC, Gastric cancer | [54, 96–101] |
| HOTAIR | Up | acting as ceRNAs | miR-19 | Cardiac hypertrophy | [105] |
| Linc-USP16 | Up | acting as ceRNAs | miR-21,miR-590-5p | HCC | [106] |
| LncRNA-BGL3 | Up | acting as ceRNAs | miR-17, miR-20a, miR-20b, miR-93, miR-106a | Chronic myeloid leukemia | [80] |
| CASC2 | Up | acting as both ceRNAs and downregulators of miRNAs | miR-21, miR-181a | Osteosarcoma, Glioma, Cervical cancer | [107–109] |
| MEG3 | Up | acting as both ceRNAs and downregulators of miRNAs | miR-1297, miR-19a, miR-21 | Breast cancer, Glioma, CAD | [111–113] |
| lncRNA GAS5 | Up | acting as both ceRNAs and downregulators of miRNAs | miR-21, miR-103, miR-196a, miR-205, miR-32-5p | HER2-positive breast cancer, HCC, NSCLC, Cardiac fibrosis, Endometrial cancer, Cervical cancer, Pancreatic cancer | [114–120] |
| XIST | Up | acting as both ceRNAs and downregulators of miRNAs | miR-181a, MiR-494 | HCC, Spinal Cord Injury | [121, 122] |
| NBAT1 | Up | acting as both ceRNAs and downregulators of miRNAs | miR-21 | Osteosarcoma | [123] |
| lnc-2 /lnc-6 | Up | acting as both ceRNAs and downregulators of miRNAs | miR-26a | Prostate cancer, Glioma | [126, 127] |
| FER1L4 | Up | acting as both ceRNAs and downregulators of miRNAs | miR-106a-5p | Colon cancer, Gastric cancer | [130, 131] |
| lincRNA-p21 | Up | acting as both ceRNAs and downregulators of miRNAs | miR-181b | Liver fibrosis | [132] |
| PTENP1 asRNA β | Up | increasing the stability and miRNA sponge activity of PTENP1 | – | – | [133] |
| HOTAIR | Down | enhancing PTEN methylation via miRNA sponging | miR-29b | Liver Fibrosis, LSCC | [134, 135] |
| PTENP1 asRNA α | Down | enhancing PTEN methylation via the recruitment of DNMT3a and EZH2 | – | – | [133] |