Fig. 1.

Inhibition of acanthosis and reduction of disease severity in let-7b^TG mice treated with IMQ. a. Phenotypic presentation of mouse back skin for wild-type and transgenic mice treated with IMQ for 7 days. b. Skin thickness was measured on the days indicated in the epidermis of wild-type and transgenic mice treated with IMQ or vehicle. Symbols represent mean skin thickness ± s.e.m. for five to six mice per group. c mPASI reflecting the intensity of skin inflammation. Two-tailed unpaired Student’s t-test was performed for statistical analysis. Data are shown as means ± s.e.m. d Light microscopy examination of skin sections stained with H&E, or with keratin K14 antibody. Scale bar, 200 μm. Scale bar in right image below, 100 μm