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. 2018 Sep 15;13:73. doi: 10.1186/s13000-018-0752-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Pathological findings of CCSLGT with EWSR1 and CREB1 rearrangements. a CCSLGTs often exhibited sheet-like proliferation of polyhedral and epithelioid tumor cells (200×). b Areas of pseudo-papillary growth pattern around the vasculatures were also observed (200×). c Tumor cells had mildly irregular-shaped round nuclei showing a coarse chromatin pattern and lightly eosinophilic to less frequently clear cytoplasm. Nucleoli were inconspicuous (400×). d Osteoclast-type giant cells were scattered in the tumor (400×). e. FISH of EWSR1 split signals. Tumor cells showed EWSR1 split signal with a pair of fused (arrow) and split (arrow head) patterns (1000×). f. FISH of CREB1 split signals. Tumor cells showed CREB1 split signal with a pair of fused (arrow) and split (arrow head) patterns (1000×)