Table 1.

MIC range, MIC₅₀ and MIC₉₀ of cefoperazone alone, cefoperazone–sulbactam (2:1), cefoperazone–sulbactam (1:1) and cefoperazone–sulbactam (1:2) against different drug-resistant organisms

MIC,	Carbapenem-resistant Enterobacteriaceae (n=57)	ESBL Escherichia coli (n=58)	ESBL Klebsiella pneumoniae (n=58)	Carbapenem-resistant Pseudomonas aeruginosa (n=49)	Carbapenem-resistant Acinetobacter baumannii (n=122)
Cefoperazone
MIC50	>64	>64	64	>64	>64
MIC90	>64	>64	>64	>64	>64
Range	8–>64	16–>64	16–>64	4–>64	64–>64
Sulbactam
MIC50	64	64	32	>64	16
MIC90	>64	>64	64	>64	32
Range	32–>64	32–>64	16–>64	8–>64	2–>64
Cefoperazone–sulbactam (2:1)
MIC50	32	8	16	64	32
MIC90	>64	32	64	>64	64
Range	4–>64	2–>64	4–>64	4–>64	4–>64
Cefoperazone–sulbactam (1:1)
MIC50	32	8	8	32	16
MIC90	>64	16	32	>64	32
Range	2–>64	1–>64	2–>64	4–>64	2–>64
Cefoperazone–sulbactam (1:2)
MIC50	16	4	4	32	8
MIC90	>64	16	16	>64	16
Range	2–>64	0.5–64	1–64	2–>64	1–>64

Abbreviations: ESBL, extended-spectrum β-lactamase; MIC, minimum inhibitory concentration.