Table 2.
Antibiotic susceptibility rates of cefoperazone alone, cefoperazone–sulbactam (2:1), cefoperazone–sulbactam (1:1) and cefoperazone–sulbactam (1:2) against different drug-resistant organisms
| Susceptibility rate (%)
|
|||||
|---|---|---|---|---|---|
| Carbapenem- resistant Enterobacteriaceae (n=57) | ESBL Escherichia coli (n=58) | ESBL Klebsiella pneumoniae (n=58) | Carbapenem-resistant Pseudomonas aeruginosa (n=49) | Carbapenem-resistant Acinetobacter baumannii (n=122) | |
| Cefoperazone | 3.5 | 3.4 | 1.7 | 24.5 | 0.0 |
| Cefoperazone–sulbactam (2:1) | 33.3a | 84.5a | 67.2a | 30.6 | 41.0a |
| Cefoperazone–sulbactam (1:1) | 49.1a | 91.4a | 75.9a | 30.6 | 76.2a,b |
| Cefoperazone–sulbactam (1:2) | 68.4a–c | 91.4a | 89.7a,b | 34.7 | 92.6a–c |
Notes: Susceptibilities of cefoperazone alone and cefoperazone–sulbactam at 2:1, 1:1 and 1:2 ratios were classified according to the MIC of cefoperazone ≤16 mg/L.
a
P-value <0.05 compared to cefoperazone.
b
P-value <0.05 compared to cefoperazone–sulbactam (2:1).
c
P-value <0.05 compared to cefoperazone–sulbactam (1:1).
Abbreviations: ESBL, extended-spectrum β-lactamase; MIC, minimum inhibitory concentration.