Table 2.

Cox proportional regression analysis to investigate the correlations of sirtuins and overall survival in patients with NSCLC

SIRTs	Univariate analysis				Multivariate analysis*
	P-value	HR	95% CI		P-value	HR	95% CI
SIRT1	0.352	0.902	0.725	1.121	0.956	1.007	0.787	1.288
SIRT2	0.007	0.736	0.588	0.920	0.005	0.697	0.543	0.894
SIRT3	0.244	0.865	0.677	1.104	0.568	0.922	0.696	1.220
SIRT4	0.043	0.761	0.584	0.992	0.255	0.842	0.626	1.132
SIRT5	0.109	0.837	0.673	1.040	0.128	0.828	0.650	1.056
SIRT6	0.044	0.780	0.612	0.994	0.009	0.684	0.514	0.911
SIRT7	0.253	0.881	0.708	1.095	0.305	0.878	0.686	1.125

Note:

^*The potential confounding factors were age, M, N, and T stage. Bold font: P<0.05 demonstrated by Cox proportional regression analysis.

Abbreviation: TCGA, The Cancer Genome Atlas; NSCLC, non-small cell lung cancer; SIRT1, sirtuin 1; SIRT2, sirtuin 2; SIRT3, sirtuin 3; SIRT4, sirtuin 4; SIRT5, sirtuin 5; SIRT6, sirtuin 6; SIRT7, sirtuin 7; HR, hazard ratio; CI, confidence interval.