Table 4.
Cox proportional regression analysis to investigate the correlations of the combination of SIRT1 and SIRT2 with recurrence-free survival in patients with NSCLC
| SIRTs | Univariate analysis
|
Multivariate analysis* | ||||||
|---|---|---|---|---|---|---|---|---|
| P-value | HR | 95% CI | P-value | HR | 95% CI | |||
| SIRT1−/SIRT2+ | Reference | |||||||
| SIRT1−/SIRT2− or SIRT1+/SIRT2+ | 0.007 | 1.758 | 1.167 | 2.648 | 0.010 | 1.746 | 1.144 | 2.665 |
| SIRT1+/SIRT2− | 0.000 | 3.134 | 2.037 | 4.820 | 0.000 | 3.021 | 1.883 | 4.849 |
Note:
*
The potential confounding factors were histology, N, and T stage. Bold font: P<0.05 demonstrated by Cox proportional regression analysis.
Abbreviations: TCGA, The Cancer Genome Atlas; NSCLC, non–small cell lung cancer; SIRT1, sirtuin 1; SIRT2, sirtuin 2; HR, hazard ratio; CI, confidence interval; +, high expression; –, low expression.