Table 5.
Associations of high sirtuins expressions with overall survival in NSCLC in previous reports
| Study | Sirtuins | HR | P value | Sample size | Detection method |
|---|---|---|---|---|---|
| Noh et al28 | SIRT1 | NS | 144 | IHC | |
| Zhang et al29 | SIRT1 | HR>1 | 0.003 | 295 | IHC |
| Grbesa et al30 | SIRT1 | NS | 105 | IHC | |
| Li et al31 | SIRT1 | HR>1 | 0.009 | 75 | IHC |
| Gharabaghi32 | SIRT1 | HR>1 | 0.001 | 40 | IHC |
| Lin and Peng33 | SIRT1 | NS | 260 | IHC | |
| Wang and Wang34 | SIRT1 | HR>1 | <0.01 | 60 | IHC |
| Grbesa et al30 | SIRT2 | NS | 105 | IHC | |
| Li et al36 | SIRT2 | HR<1 | <0.01 | 28 | PCR |
| Yang et al37 | SIRT3 | HR>1 | 0.001 | 131 | IHC |
| Xiong et al38 | SIRT3 | HR>1 | 0.028 | 70 | IHC |
| Lu et al39 | SIRT5 | HR>1 | 0.03 | 39 | PCR |
| Azuma et al40 | SIRT6 | HR>1 | 0.022 | 98 | IHC |
| Bai et al41 | SIRT6 | HR>1 | 0.034 | 174 | IHC |
| Chen et al42 | SIRT6 | HR>1 | <0.01 | 122 | IHC |
Abbreviations: NSCLC, non–small cell lung cancer; NS, not significant; SIRT1, sirtuin 1; SIRT2, sirtuin 2; SIRT3, sirtuin 3; SIRT5, sirtuin 5; SIRT6, sirtuin 6; HR, hazard ratio; IHC, immunohistochemistry; PCR, polymerase chain reaction.