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Covalent capture of specific nucleic acid sequences by interstrand cross-link formation. Panel A. Covalent cross-link formation by reaction of Ap aldehyde residue in probe strand with adenine residue in target sequence. Panel B. Sequence motif for dA-Ap cross-linking reaction. Panel C. Sequence-specific covalent capture of the mutant BRAF gene sequence by an Ap-containing probe strand.
