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Incremental current decreases induced by sequential, irreversible blocking of individual α-HL pores by cross-linked duplexes in an experiment with multiple channels embedded in the lipid bilayer. The mixture contained cross-linked duplex, uncross-linked duplex, and single strands. The analysis was carried out at 120 mV in Tris buffer (10 mM, pH 7.4) containing KCl (1 M) at 22 ℃. The trace shown was low-pass filtered at 1 kHz.
