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. Author manuscript; available in PMC: 2019 Sep 15.
Published in final edited form as: Cancer Res. 2018 Jul 16;78(18):5203–5215. doi: 10.1158/0008-5472.CAN-17-3615

Figure 4. Reactivity with pYpY antibody correlates with BMX activity in vivo.

Figure 4

(A) Castration resistant VCaP xenografts were immunostained for total BMX or pYpY, the latter with or without (D/E/S/T)pYpY peptide blocking. (B) Castration resistant VCaP xenograft bearing mice were administered 100 mg/kg/d of BMX-IN-1 for 4 days. Pretreatment biopsies and post treatment tissues were immunostained for pYpY. (C) Bone metastasis biopsies from patients with CRPC were immunostained for pYpY and BMX. (D and E) Tissue microarrays of human PCa were immunostained for pYpY and BMX (D) and scored for correlation between pYpY and BMX (E).