Figure 1.

Aged mice expressing the non-AD related ApoE3 allele show normal SWR abundance and SWR-associated slow gamma, and perform well in memory tasks. Conversely, aged mice expressing the AD-related ApoE4 allele have reduced SWR abundance, decreased SWR-associated slow gamma, and impaired learning and memory. Importantly, when the ApoE4 mutation is eliminated from GABAergic interneurons, SWR-associated slow gamma deficits are alleviated, and learning and memory impairments do not develop. This indicates that SWR-associated slow gamma is crucial for normal learning and memory in this aged AD model. Reproduced with permission from [23].