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. Author manuscript; available in PMC: 2019 Sep 15.
Published in final edited form as: Cancer Res. 2018 Aug 2;78(18):5431–5445. doi: 10.1158/0008-5472.CAN-17-3811

Fig. 3. Bioinformatic analyses revealed RAB38 as a potential driver for melanoma progression. (A).

Fig. 3

Kaplan-Meier plot of overall patient survival stratified by median RAB38 mRNA expression in the skin cutaneous melanoma (SKCM) cohort in The Cancer Genome Atlas (TCGA) database. Log-rank test p-value is displayed; (B) Box plot showing enriched RAB38 mRNA expressions in SKCM and uveal melanoma (UVM) in TCGA database; (C) Scatter plot showing up-regulated RAB38 mRNA expression in various metastatic melanoma cell lines (highlighted as black dots) in the NCI-60 Human Tumor Cell Lines Database; (D) Scatter plot showing up-regulated RAB38 mRNA expressions in melanoma cell lines in the Cancer Cell Line Encyclopedia (CCLE) Database; (E) Scattered plot showing up-regulated RAB38 mRNA expressions in various metastatic melanoma cell lines (highlighted as dark grey dots) in the CCLE Database; (F) RAB38 mRNA levels were significantly up-regulated in the highly metastatic derivatives of A375 cells cell lines compared to the poorly metastatic A375 parental cells (GEO data series: GSE7929). The p values were calculated by using an unpaired two-tailed Student’s t test.