Table 1.

Relations among age, recall output and volume of PFC ROIs.

PFC Region		Age		# Semantic Clustering Score		# Serial Clustering Score		# Words Recalled
		r	p	r	p	r	p	r	p
Superior Frontal	Left	−0.52	<0.001	−0.27	0.003	0.01	0.88	−0.43	<0.001
	Right	−0.45	<0.001	−0.21	0.03	0.06	0.54	−0.30	0.001
Rostral Middle Frontal	Left	−0.41	<0.001	−0.19	0.04	0.04	0.63	−0.29	0.001
	Right	−0.35	<0.001	−0.29M	0.001	0.10	0.27	−0.28	0.002
Caudal Middle Frontal	Left	−0.27	0.004	−0.16	0.08	0.07	0.47	−0.17	0.07
	Right	−0.35	<0.001	−0.30M	0.001	0.15	0.11	−0.22	0.02
Inferior Frontal	Left	−0.53	<0.001	−0.28	0.003	−0.01	0.93	−0.38	<0.001
	Right	−0.49	<0.001	−0.13	0.17	−0.05	0.60	−0.34	<0.001
Lateral Orbitofrontal	Left	−0.41	<0.001	−0.17	0.07	0.06	0.52	−0.34	<0.001
	Right	−0.41	<0.001	−0.10	0.29	−0.05	0.56	−0.32	<0.001
Medial Orbitofrontal	Left	−0.35	<0.001	−0.08	0.37	−0.10	0.26	−0.33	<0.001
	Right	−0.38	<0.001	−0.11	0.26	−0.001	0.99	−0.37	<0.001

Partial correlation coefficients and significance presented for relationship between volume of each PFC ROI with age, semantic clustering score, serial clustering score, and number of words recalled. Effects were tested separately for left and right volumes for all the ROIs, including superior frontal, rostral middle frontal, caudal middle frontal, inferior frontal, lateral orbitofrontal and medial orbitofrontal lobes. All correlations are controlled for sex. Bold, significant correlations after FDR correction for multiple comparisons.

^Mregional volumes significantly mediated the relation between age and performance indices.