Table 2.
Association between H19 SNPs and risks of lung adenocarcinoma and squamous cell lung cancer
| H19 | Controls (%) | Lung Adenocarcinoma | Squamous cell lung cancer | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases (%) | OR (95% CI) | P value | OR (95% CI)* | P value | Cases (%) | OR (95% CI) | P value | OR (95% CI)* | P value | |||
| rs217727 | CC | 165(41.8) | 141(38.0) | 1.00(ref) | 1.00(ref) | 35(36.5) | 1.00(ref) | 1.00(ref) | ||||
| CT | 172(43.5) | 169(45.6) | 1.150(0.844–1.566) | 0.376 | 1.152(0.846–1.570) | 0.369 | 45(46.9) | 1.233(0.755–2.015) | 0.402 | 1.236(0.756–2.022) | 0.399 | |
| TT | 58(14.7) | 61(16.4) | 1.231(0.805–1.881) | 0.337 | 1.231(0.806–1.881) | 0.337 | 16(16.7) | 1.300(0.670–2.523) | 0.437 | 1.315(0.676–2.556) | 0.420 | |
| CT + TT vs CC | 1.170(0.876–1.563) | 0.288 | 1.172(0.877–1.566) | 0.283 | 1.250(0.788–1.983) | 0.342 | 1.256(0.791–1.994) | 0.335 | ||||
| TT vs CT + CC | 1.143(0.773–1.691) | 0.502 | 1.142(0.773–1.689) | 0.505 | 1.162(0.635–2.128) | 0.626 | 1.173(0.640–2.153) | 0.605 | ||||
| C allele | 502(63.5) | 451(60.8) | 1.00(ref) | 115(59.9) | 1.00(ref) | |||||||
| T allele | 288(36.5) | 291(39.2) | 1.125(0.915–1.383) | 0.265 | 77(3.6) | 1.167(0.845–1.612) | 0.384 | |||||
| rs2107425 | CC | 140(35.4) | 111(29.9) | 1.00(ref) | 1.00(ref) | 27(28.1) | 1.00(ref) | 1.00(ref) | ||||
| CT | 185(46.8) | 171(46.1) | 1.166(0.843–1.613) | 0.354 | 1.166(0.843–1.613) | 0.354 | 43(44.8) | 1.205(0.710–2.045) | 0.489 | 1.183(0.696–2.011) | 0.536 | |
| TT | 70(17.7) | 89(24.0) | 1.604(1.075–2.393) | 0.021 | 1.602(1.074–2.390) | 0.021 | 26(27.1) | 1.926(1.046–3.545) | 0.035 | 1.935(1.049–3.570) | 0.035 | |
| CT + TT vs CC | 1.286(0.950–1.741) | 0.104 | 1.286(0.949–1.741) | 0.104 | 1.403(0.859–2.291) | 0.176 | 1.387(0.848–2.268) | 0.192 | ||||
| CC vs CT + TT | 1.465(1.031–2.082) | 0.033 | 1.464(1.030–2.080) | 0.034 | 1.724(1.026–2.898) | 0.040 | 1.752(1.040–2.952) | 0.035 | ||||
| C allele | 465(58.9) | 393(53.0) | 1.00(ref) | 97(50.5) | 1.00(ref) | |||||||
| T allele | 325(41.1) | 349(47.0) | 1.271(1.038–1.555) | 0.020 | 95(49.5) | 1.401(1.021–1.923) | 0.036 | |||||
| rs2735469 | CC | 359(90.9) | 340(91.6) | 1.00(ref) | 1.00(ref) | 89(92.7) | 1.00(ref) | 1.00(ref) | ||||
| CT | 36(9.1) | 29(7.8) | 0.851(0.510–1.418) | 0.535 | 0.851(0.510–1.418) | 0.535 | 6(6.3) | 0.672(0.275–1.645) | 0.384 | 0.662(0.270–1.624) | 0.368 | |
| TT | 0(0) | 2(0.5) | # | # | # | # | 1(1.0) | # | # | # | # | |
| CT + TT vs CC | 0.909(0.550–1.503) | 0.711 | 0.910(0.550–1.504) | 0.712 | 0.784(0.338–1.821) | 0.572 | 0.775(0.333–1.803) | 0.554 | ||||
| TT vs CC + CT | # | # | # | # | # | # | # | # | ||||
| C allele | 754(95.4) | 709(95.6) | 1.00(ref) | 184(95.8) | 1.00(ref) | |||||||
| T allele | 36(4.6) | 33(4.4) | 0.975(0.601–1.581) | 0.918 | 8(4.2) | 0.911(0.416–1.992) | 0.815 | |||||
| rs17658052 | GG | 371(93.9) | 343(92.4) | 1.00(ref) | 1.00(ref) | 82(85.4) | 1.00(ref) | 1.00(ref) | ||||
| AG | 24(6.1) | 27(7.3) | 1.217(0.689–2.150) | 0.499 | 1.212(0.685–2.142) | 0.509 | 13(13.5) | 2.451(1.198–5.015) | 0.014 | 2.411(1.175–4.946) | 0.016 | |
| AA | 0(0.0) | 1(0.3) | # | # | # | # | 1(1.0) | # | # | # | # | |
| AG + AA vs GG | 1.262(0.717–2.219) | 0.419 | 1.256(0.714–2.211) | 0.429 | 2.639(1.309–5.321) | 0.007 | 2.587(1.279–5.229) | 0.008 | ||||
| AA vs GG + AG | # | # | # | # | # | # | # | # | ||||
| G allele | 766(96.9) | 713(96.1) | 1.00(ref) | 0.410 | 177(92.2) | 1.00(ref) | ||||||
| A allele | 24(3.0) | 29(3.9) | 1.298(0.749–2.251) | 0.352 | 15(7.8) | 2.705(1.390–5.262) | 0.002 | |||||
*: adjusted by age
#: could not be calculated