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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Dev Psychobiol. 2018 May 10;60(5):520–533. doi: 10.1002/dev.21632

Figure 1.

Figure 1.

Timeline representations for the Experimental Timeline (A). Rats were exposed to neonatal pain and stress manipulations during the first week of life. Then underwent a 3-day fear conditioning protocol across subsequent days in different age cohorts starting at PND 24 (post-weaning), 45 (adolescence), or 66 (adulthood). Sensory testing occurred on the fourth day. The timeline for the neonatal manipulation (B) occurred from PND 1–7. Arrows represent experiment-specific insults, a single needle prick(occurring 4 times per day) for the acute pain experiments and an i.pl. injection for the inflammatory pain experiment.